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DNA Research 1998 5(3):177-186; doi:10.1093/dnares/5.3.177
© 1998 by Kazusa DNA Research Institute
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The Primary Structure and Genomic Organization of Five Novel Transcripts Located Close to the Huntington's Disease Gene on Human Chromosome 4p16.3

Shinji Hadano1 {dagger}, Yoshikazu Ishida2 and Joh-E. Ikeda1,3,*

1NeuroGenes, International Cooperative Research Project (ICORP), Japan Science and Technology Corporation (JST), Tokai University School of Medicine Bohseidai, Isehara-city, Kanagawa 259-1193, Japan
2Tsuruga Institute of Biotechnology, Toyobo Co., Ltd. Toyo-cho, Tsuruga, Fukui 914, Japan
3Department of Molecular Neuroscience, Molecular Medicine Research Center, The Institute of Medical Sciences, Tokai University Bohseidai, Isehara-city, Kanagawa 259-1193, Japan

* To whom correspondence should be addressed. Tel. +81-463-91-5095, Fax. +81-463-91-4993, E-mail: joh-e{at}nga.med.utokai.ac.jp

Five distinct noveltranscripts (RES4-22, -23, -24, -25 and -26) that mapped to the 1-Mb interval between D4S180 and D4S183 on human chromosome 4p16.3 close to the Huntington's disease (HD) gene were isolated, and the structure and exon/intron organization of each gene were thoroughly analyzed. The transcripts of the RES4-22, -23 and -24 genes each have several isoforms by alternative splicing and these have also been defined. Two transcripts, RES4-24 and RES4-25, reside in the same genomic region with opposite polarities and they also clearly overlap. Among these transcripts, RES4-26 was found to encode a novel zinc finger protein. The transcript map based upon our current level of analysis combined with data from previous studies reveals the gene-rich nature and the intricate organization of the genes in the HD locus.

Key words: novel transcript; transcript map; human chromosome 4p16.3; Huntington's disease

{dagger} Present address: Centre for Molecular Medicine and Therapeutics, University of British Columbia, Rm 3004, 950 West 28th Ave., Vancouver, British Columbia V5Z 4H4, Canada


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