© 1997 by Kazusa DNA Research Institute
Compilation of All Genes Encoding Two-component Phosphotransfer Signal Transducers in the Genome of Escherichia coli
Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University Chikusa-ku, Nagoya 464, Japan
* To whom correspondence should be addressed. Tel. +81-52-789-4089, Fax. +81-52-789-4091
Bacteria have devised sophisticated His-Asp phosphorelay signaling systems for eliciting a variety of adaptive responses to their environment, which are generally referred to as the "two-component regulatory system." The widespread occurrence of the His-Asp phosphorelay signaling in both prokaryotes and eukaryotes implies that it is a powerful device for a wide variety of adaptive responses of cells to their environment. The two-component signal transducers contain one or more of three common and characteristic phosphotransfer signaling domains, named the "transmitter, receiver, and histidine-containing phosphotransfer (HPt) domains." The recently determined entire genomic sequence of Escherichia coli allowed us to compile systematically a complete list of genes encoding such two-component signal transduction proteins. The results of such an effort, made in this study, revealed that at least 62 open reading frames(ORFs) were identified as putative members of the two-component signaltransducers in this single species. Among them, 32 were identified as response regulator and 23 were identified as orthodox sensory kinases. In addition, E. coli has five hybrid sensory kinases. The precise location of each ORF was mapped on a physical map of the entire E. coli genome. All of these ORFs were then compiled and annotated extensively.
Key words: Escherichia coli MG1655; two-component regulatory system; response regulator; sensory kinase
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y.-F. Ma, Y. Zhang, J.-Y. Zhang, D.-W. Chen, Y. Zhu, H. Zheng, S.-Y. Wang, C.-Y. Jiang, G.-P. Zhao, and S.-J. Liu The Complete Genome of Comamonas testosteroni Reveals Its Genetic Adaptations to Changing Environments Appl. Envir. Microbiol., November 1, 2009; 75(21): 6812 - 6819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ishida, Y. Niwa, T. Yamashino, and T. Mizuno A Genome-Wide Compilation of the Two-Component Systems in Lotus japonicus DNA Res, August 1, 2009; 16(4): 237 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Gupta, B. N. Borin, T. L. Cover, and A. M. Krezel Structural Analysis of the DNA-binding Domain of the Helicobacter pylori Response Regulator ArsR J. Biol. Chem., March 6, 2009; 284(10): 6536 - 6545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Shrivastava, A. K. Ghosh, and A. K. Das Intra- and intermolecular domain interactions among novel two-component system proteins coded by Rv0600c, Rv0601c and Rv0602c of Mycobacterium tuberculosis Microbiology, March 1, 2009; 155(3): 772 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Al-Khodor, S. Kalachikov, I. Morozova, C. T. Price, and Y. Abu Kwaik The PmrA/PmrB Two-Component System of Legionella pneumophila Is a Global Regulator Required for Intracellular Replication within Macrophages and Protozoa Infect. Immun., January 1, 2009; 77(1): 374 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Argyros, D. E. Mathews, Y.-H. Chiang, C. M. Palmer, D. M. Thibault, N. Etheridge, D. A. Argyros, M. G. Mason, J. J. Kieber, and G. E. Schaller Type B Response Regulators of Arabidopsis Play Key Roles in Cytokinin Signaling and Plant Development PLANT CELL, August 1, 2008; 20(8): 2102 - 2116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Whitworth and P. J. A. Cock Two-component systems of the myxobacteria: structure, diversity and evolutionary relationships Microbiology, February 1, 2008; 154(2): 360 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Eguchi, J. Itou, M. Yamane, R. Demizu, F. Yamato, A. Okada, H. Mori, A. Kato, and R. Utsumi B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli PNAS, November 20, 2007; 104(47): 18712 - 18717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Hussa, T. M. O'Shea, C. L. Darnell, E. G. Ruby, and K. L. Visick Two-Component Response Regulators of Vibrio fischeri: Identification, Mutagenesis, and Characterization J. Bacteriol., August 15, 2007; 189(16): 5825 - 5838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Schaller, K. Doi, I. Hwang, J. J. Kieber, J. P. Khurana, N. Kurata, T. Mizuno, A. Pareek, S.-H. Shiu, P. Wu, et al. Nomenclature for Two-Component Signaling Elements of Rice Plant Physiology, February 1, 2007; 143(2): 555 - 557. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Mascher, J. D. Helmann, and G. Unden Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases Microbiol. Mol. Biol. Rev., December 1, 2006; 70(4): 910 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pareek, A. Singh, M. Kumar, H. R. Kushwaha, A. M. Lynn, and S. L. Singla-Pareek Whole-Genome Analysis of Oryza sativa Reveals Similar Architecture of Two-Component Signaling Machinery with Arabidopsis Plant Physiology, October 1, 2006; 142(2): 380 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Herren, A. Mitra, S. K. Palaniyandi, A. Coleman, S. Elankumaran, and S. Mukhopadhyay The BarA-UvrY Two-Component System Regulates Virulence in Avian Pathogenic Escherichia coli O78:K80:H9. Infect. Immun., August 1, 2006; 74(8): 4900 - 4909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Chow and P. McCourt Plant hormone receptors: perception is everything Genes & Dev., August 1, 2006; 20(15): 1998 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gao, A. Mukhopadhyay, F. Fang, and D. G. Lynn Constitutive Activation of Two-Component Response Regulators: Characterization of VirG Activation in Agrobacterium tumefaciens. J. Bacteriol., July 1, 2006; 188(14): 5204 - 5211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Pruss, C. Besemann, A. Denton, and A. J. Wolfe A Complex Transcription Network Controls the Early Stages of Biofilm Development by Escherichia coli J. Bacteriol., June 1, 2006; 188(11): 3731 - 3739. [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Galperin Structural classification of bacterial response regulators: diversity of output domains and domain combinations. J. Bacteriol., June 1, 2006; 188(12): 4169 - 4182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-P. Castanie-Cornet, K. Cam, and A. Jacq RcsF Is an Outer Membrane Lipoprotein Involved in the RcsCDB Phosphorelay Signaling Pathway in Escherichia coli. J. Bacteriol., June 1, 2006; 188(12): 4264 - 4270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nadler, Y. Shifrin, S. Nov, S. Kobi, and I. Rosenshine Characterization of Enteropathogenic Escherichia coli Mutants That Fail To Disrupt Host Cell Spreading and Attachment to Substratum Infect. Immun., February 1, 2006; 74(2): 839 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tomenius, A.-K. Pernestig, C. F. Mendez-Catala, D. Georgellis, S. Normark, and O. Melefors Genetic and Functional Characterization of the Escherichia coli BarA-UvrY Two-Component System: Point Mutations in the HAMP Linker of the BarA Sensor Give a Dominant-Negative Phenotype J. Bacteriol., November 1, 2005; 187(21): 7317 - 7324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O. d. O. Lucana, P. Zou, M. Nierhaus, and H. Schrempf Identification of a novel two-component system SenS/SenR modulating the production of the catalase-peroxidase CpeB and the haem-binding protein HbpS in Streptomyces reticuli Microbiology, November 1, 2005; 151(11): 3603 - 3614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Mason, D. E. Mathews, D. A. Argyros, B. B. Maxwell, J. J. Kieber, J. M. Alonso, J. R. Ecker, and G. E. Schaller Multiple Type-B Response Regulators Mediate Cytokinin Signal Transduction in Arabidopsis PLANT CELL, November 1, 2005; 17(11): 3007 - 3018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Majdalani, M. Heck, V. Stout, and S. Gottesman Role of RcsF in Signaling to the Rcs Phosphorelay Pathway in Escherichia coli J. Bacteriol., October 1, 2005; 187(19): 6770 - 6778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. Vemuri and A. A. Aristidou Metabolic Engineering in the -omics Era: Elucidating and Modulating Regulatory Networks Microbiol. Mol. Biol. Rev., June 1, 2005; 69(2): 197 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kneuper, I. G. Janausch, V. Vijayan, M. Zweckstetter, V. Bock, C. Griesinger, and G. Unden The Nature of the Stimulus and of the Fumarate Binding Site of the Fumarate Sensor DcuS of Escherichia coli J. Biol. Chem., May 27, 2005; 280(21): 20596 - 20603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Mizuno and N. Nakamichi Pseudo-Response Regulators (PRRs) or True Oscillator Components (TOCs) Plant Cell Physiol., May 1, 2005; 46(5): 677 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nishino, T. Honda, and A. Yamaguchi Genome-Wide Analyses of Escherichia coli Gene Expression Responsive to the BaeSR Two-Component Regulatory System J. Bacteriol., March 1, 2005; 187(5): 1763 - 1772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamamoto, K. Hirao, T. Oshima, H. Aiba, R. Utsumi, and A. Ishihama Functional Characterization in Vitro of All Two-component Signal Transduction Systems from Escherichia coli J. Biol. Chem., January 14, 2005; 280(2): 1448 - 1456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ohashi, T. Yamashino, and T. Mizuno Molecular Basis for Promoter Selectivity of the Transcriptional Activator OmpR of Escherichia coli: Isolation of Mutants That Can Activate the Non-Cognate kdpABC Promoter J. Biochem., January 1, 2005; 137(1): 51 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Mason, J. Li, D. E. Mathews, J. J. Kieber, and G. E. Schaller Type-B Response Regulators Display Overlapping Expression Patterns in Arabidopsis Plant Physiology, June 1, 2004; 135(2): 927 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Eguchi, T. Okada, S. Minagawa, T. Oshima, H. Mori, K. Yamamoto, A. Ishihama, and R. Utsumi Signal Transduction Cascade between EvgA/EvgS and PhoP/PhoQ Two-Component Systems of Escherichia coli J. Bacteriol., May 15, 2004; 186(10): 3006 - 3014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Catlett, O. C. Yoder, and B. G. Turgeon Whole-Genome Analysis of Two-Component Signal Transduction Genes in Fungal Pathogens Eukaryot. Cell, December 1, 2003; 2(6): 1151 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wen, E. A. Marcus, U. Matrubutham, M. A. Gleeson, D. R. Scott, and G. Sachs Acid-Adaptive Genes of Helicobacter pylori Infect. Immun., October 1, 2003; 71(10): 5921 - 5939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hagiwara, M. Sugiura, T. Oshima, H. Mori, H. Aiba, T. Yamashino, and T. Mizuno Genome-Wide Analyses Revealing a Signaling Network of the RcsC-YojN-RcsB Phosphorelay System in Escherichia coli J. Bacteriol., October 1, 2003; 185(19): 5735 - 5746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hirakawa, K. Nishino, J. Yamada, T. Hirata, and A. Yamaguchi {beta}-Lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli J. Antimicrob. Chemother., October 1, 2003; 52(4): 576 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Dwyer, L. L. Looger, and H. W. Hellinga Computational design of a Zn2+ receptor that controls bacterial gene expression PNAS, September 30, 2003; 100(20): 11255 - 11260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. MacConaill, D. Butler, M. O'Connell-Motherway, G. F. Fitzgerald, and D. van Sinderen Identification of Two-Component Regulatory Systems in Bifidobacterium infantis by Functional Complementation and Degenerate PCR Approaches Appl. Envir. Microbiol., July 1, 2003; 69(7): 4219 - 4226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Minagawa, H. Ogasawara, A. Kato, K. Yamamoto, Y. Eguchi, T. Oshima, H. Mori, A. Ishihama, and R. Utsumi Identification and Molecular Characterization of the Mg2+ Stimulon of Escherichia coli J. Bacteriol., July 1, 2003; 185(13): 3696 - 3702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hirakawa, K. Nishino, T. Hirata, and A. Yamaguchi Comprehensive Studies of Drug Resistance Mediated by Overexpression of Response Regulators of Two-Component Signal Transduction Systems in Escherichia coli J. Bacteriol., March 15, 2003; 185(6): 1851 - 1856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-K. Pernestig, D. Georgellis, T. Romeo, K. Suzuki, H. Tomenius, S. Normark, and O. Melefors The Escherichia coli BarA-UvrY Two-Component System Is Needed for Efficient Switching between Glycolytic and Gluconeogenic Carbon Sources J. Bacteriol., February 1, 2003; 185(3): 843 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Walthers, V. K. Tran, and L. J. Kenney Interdomain Linkers of Homologous Response Regulators Determine Their Mechanism of Action J. Bacteriol., January 1, 2003; 185(1): 317 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hancock and M. Perego Two-Component Signal Transduction in Enterococcus faecalis J. Bacteriol., November 1, 2002; 184(21): 5819 - 5825. [Full Text] [PDF]
|
|
|
|
|
|
K. Yamaguchi, I. Suzuki, H. Yamamoto, A. Lyukevich, I. Bodrova, D. A. Los, I. Piven, V. Zinchenko, M. Kanehisa, and N. Murata A Two-Component Mn2+-Sensing System Negatively Regulates Expression of the mntCAB Operon in Synechocystis PLANT CELL, November 1, 2002; 14(11): 2901 - 2913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hosoda, A. Imamura, E. Katoh, T. Hatta, M. Tachiki, H. Yamada, T. Mizuno, and T. Yamazaki Molecular Structure of the GARP Family of Plant Myb-Related DNA Binding Motifs of the Arabidopsis Response Regulators PLANT CELL, September 1, 2002; 14(9): 2015 - 2029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Cai and M. Inouye EnvZ-OmpR Interaction and Osmoregulation in Escherichia coli J. Biol. Chem., June 28, 2002; 277(27): 24155 - 24161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Nikolskaya and M. Y. Galperin A novel type of conserved DNA-binding domain in the transcriptional regulators of the AlgR/AgrA/LytR family Nucleic Acids Res., June 1, 2002; 30(11): 2453 - 2459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nishino and A. Yamaguchi EvgA of the Two-Component Signal Transduction System Modulates Production of the YhiUV Multidrug Transporter in Escherichia coli J. Bacteriol., April 15, 2002; 184(8): 2319 - 2323. [Abstract] [Full Text]
|
|
|
|
|
|
I. Martinez-Argudo, P. Salinas, R. Maldonado, and A. Contreras Domain Interactions on the ntr Signal Transduction Pathway: Two-Hybrid Analysis of Mutant and Truncated Derivatives of Histidine Kinase NtrB J. Bacteriol., January 1, 2002; 184(1): 200 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Verhamme, J. C. Arents, P. W. Postma, W. Crielaard, and K. J. Hellingwerf Investigation of in vivo cross-talk between key two-component systems of Escherichia coli Microbiology, January 1, 2002; 148(1): 69 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Verhamme, J. C. Arents, P. W. Postma, W. Crielaard, and K. J. Hellingwerf Glucose-6-phosphate-dependent phosphoryl flow through the Uhp two-component regulatory system Microbiology, December 1, 2001; 147(12): 3345 - 3352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ogura, H. Yamaguchi, K.-i. Yoshida, Y. Fujita, and T. Tanaka DNA microarray analysis of Bacillus subtilis DegU, ComA and PhoP regulons: an approach to comprehensive analysis of B.subtilis two-component regulatory systems Nucleic Acids Res., September 15, 2001; 29(18): 3804 - 3813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Hoch and K. I. Varughese Keeping Signals Straight in Phosphorelay Signal Transduction J. Bacteriol., September 1, 2001; 183(17): 4941 - 4949. [Full Text] [PDF]
|
|
|
|
|
|
D.-j. Kim and S. Forst Genomic analysis of the histidine kinase family in bacteria and archaea Microbiology, May 1, 2001; 147(5): 1197 - 1212. [Abstract] [Full Text]
|
|
|
|
|
|
T. Arcondeguy, R. Jack, and M. Merrick PII Signal Transduction Proteins, Pivotal Players in Microbial Nitrogen Control Microbiol. Mol. Biol. Rev., March 1, 2001; 65(1): 80 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Suzuki, K. Miwa, K. Ishikawa, H. Yamada, H. Aiba, and T. Mizuno The Arabidopsis Sensor His-kinase, AHK4, Can Respond to Cytokinins Plant Cell Physiol., February 1, 2001; 42(2): 107 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Matsushika, S. Makino, M. Kojima, and T. Mizuno Circadian Waves of Expression of the APRR1/TOC1 Family of Pseudo-Response Regulators in Arabidopsis thaliana: Insight into the Plant Circadian Clock Plant Cell Physiol., September 1, 2000; 41(9): 1002 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Beier and R. Frank Molecular Characterization of Two-Component Systems of Helicobacter pylori J. Bacteriol., April 15, 2000; 182(8): 2068 - 2076. [Abstract] [Full Text]
|
|
|
|
|
|
M. Ansaldi, G. Simon, M. Lepelletier, and V. Méjean The TorR High-Affinity Binding Site Plays a Key Role in Both torR Autoregulation and torCAD Operon Expression in Escherichia coli J. Bacteriol., February 15, 2000; 182(4): 961 - 966. [Abstract] [Full Text]
|
|
|
|
|
|
D. Yan, H. S. Cho, C. A. Hastings, M. M. Igo, S.-Y. Lee, J. G. Pelton, V. Stewart, D. E. Wemmer, and S. Kustu Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators PNAS, December 21, 1999; 96(26): 14789 - 14794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. Garnerone, D. Cabanes, M. Foussard, P. Boistard, and J. Batut Inhibition of the FixL Sensor Kinase by the FixT Protein in Sinorhizobium meliloti J. Biol. Chem., November 5, 1999; 274(45): 32500 - 32506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Urao, B. Yakubov, R. Satoh, K. Yamaguchi-Shinozaki, M. Seki, T. Hirayama, and K. Shinozaki A Transmembrane Hybrid-Type Histidine Kinase in Arabidopsis Functions as an Osmosensor PLANT CELL, September 1, 1999; 11(9): 1743 - 1754. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. J. Hilliard, R. M. Goldschmidt, L. Licata, E. Z. Baum, and K. Bush Multiple Mechanisms of Action for Inhibitors of Histidine Protein Kinases from Bacterial Two-Component Systems Antimicrob. Agents Chemother., July 1, 1999; 43(7): 1693 - 1699. [Abstract] [Full Text]
|
|
|
|
|
|
I. Hwang, T. Thorgeirsson, J. Lee, S. Kustu, and Y.-K. Shin Physical evidence for a phosphorylation-dependent conformational change in the enhancer-binding protein NtrC PNAS, April 27, 1999; 96(9): 4880 - 4885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fabret, V. A. Feher, and J. A. Hoch Two-Component Signal Transduction in Bacillus subtilis: How One Organism Sees Its World J. Bacteriol., April 1, 1999; 181(7): 1975 - 1983. [Full Text]
|
|
|
|
|
|
D. Georgellis, O. Kwon, P. De Wulf, and E. C. C. Lin Signal Decay through a Reverse Phosphorelay in the Arc Two-component Signal Transduction System J. Biol. Chem., December 4, 1998; 273(49): 32864 - 32869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Matsushika and T. Mizuno A Dual-Signaling Mechanism Mediated by the ArcB Hybrid Sensor Kinase Containing the Histidine-Containing Phosphotransfer Domain in Escherichia coli J. Bacteriol., August 1, 1998; 180(15): 3973 - 3977. [Abstract] [Full Text]
|
|
|
|
|
|
A. Imamura, N. Hanaki, H. Umeda, A. Nakamura, T. Suzuki, C. Ueguchi, and T. Mizuno Response regulators implicated in His-to-Asp phosphotransfer signaling in Arabidopsis PNAS, March 3, 1998; 95(5): 2691 - 2696. [Abstract] [Full Text] [PDF]
|
|