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DNA Research 2000 7(3):229-231; doi:10.1093/dnares/7.3.229
© 2000 by Kazusa DNA Research Institute
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Structurally and Functionally Distinct Mouse Hsp70 Family Members Mot-1 and Mot-2 Proteins are Encoded by Two Alleles

Sunil C. Kaul1, Emma Duncan1, Takashi Sugihara2, Roger R. Reddel3, Youji Mitsui1 and Renu Wadhwa2,*

1National Institute of Bioscience and Human-Technology, AIST 1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan
2Chugai Research Institute for Molecular Medicine 153-2 Nagai, Niihari-mura, Ibaraki 300-41, Japan
3Children's Medical Research Institute 214 Hawkesbury Road, Westmead-2145, NSW, Australia

* To whom correspondence should be addressed. Tel. +81-298-30-6211, Fax. +81-298-30-6270, E-mail: renu{at}cimmed.com

The mouse mortalin proteins Mot-1 and Mot-2 differ by two amino acids in their carboxy-terminus. These proteins are differentially localized in the cell cytoplasm and have contrasting biological activities. The genetic relationship between Mot-1 and Mot-2 was deciphered by mouse family analyses. Mot-1 and Mot-2 segregated in F1 and F2 progeny, providing direct evidence that the two proteins are encoded by two alleles.

Key words: Mot-1; Mot-2; alleles


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