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DNA Research Advance Access originally published online on February 7, 2008
DNA Research 2008 15(1):39-47; doi:10.1093/dnares/dsm030
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© The Author 2008. Kazusa DNA Research Institute
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Complete Genome Sequence of Finegoldia magna, an Anaerobic Opportunistic Pathogen

Takatsugu Goto1,*, Atsushi Yamashita2, Hideki Hirakawa3, Minenosuke Matsutani4, Kozo Todo1,5, Kenshiro Ohshima2,6, Hidehiro Toh2,7, Kazuaki Miyamoto1, Satoru Kuhara4, Masahira Hattori2,6,8, Tohru Shimizu9 and Shigeru Akimoto1

1 Department of Microbiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama 641-0012, Japan
2 Laboratory of Genomic Information, Kitasato Institute for Life Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan
3 Graduate School of Systems Life Sciences, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
4 Graduate School of Genetic Resource Technology, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
5 Department of Oral and Maxillofacial Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama 641-0012, Japan
6 Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashinoha, Kashiwa, Chiba 277-8561, Japan
7 Computational and Experimental Systems Biology Group, RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
8 Genome Core Technology Facility, RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
9 Department of Bacteriology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan

Received 23 October 2007 ; accepted 5 December 2007.

Finegoldia magna (formerly Peptostreptococcus magnus), a member of the Gram-positive anaerobic cocci (GPAC), is a commensal bacterium colonizing human skin and mucous membranes. Moreover, it is also recognized as an opportunistic pathogen responsible for various infectious diseases. Here, we report the complete genome sequence of F. magna ATCC 29328. The genome consists of a 1 797 577 bp circular chromosome and an 189 163 bp plasmid (pPEP1). The metabolic maps constructed based on the genome information confirmed that most F. magna strains cannot ferment most sugars, except fructose, and have various aminopeptidase activities. Three homologs of albumin-binding protein, a known virulence factor useful for antiphagocytosis, are encoded on the chromosome, and one albumin-binding protein homolog is encoded on the plasmid. A unique feature of the genome is that F. magna encodes many sortase genes, of which substrates may be involved in bacterial pathogenesis, such as antiphagocytosis and adherence to the host cell. The plasmid pPEP1 encodes seven sortase and seven substrate genes, whereas the chromosome encodes four sortase and 19 substrate genes. These plasmid-encoded sortases may play important roles in the pathogenesis of F. magna by enriching the variety of cell wall anchored surface proteins.

Key words: whole genome sequence; Gram-positive anaerobic cocci; Peptostreptococcus magnus; albumin-binding protein; sortase

* To whom correspondence should be addressed. Tel. +81 73-441-0640. Fax. +81 73-448-1026. E-mail: t-goto{at}wakayama-med.ac.jp

Edited by Satoshi Tabata


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