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DNA Research Advance Access originally published online on January 16, 2006
DNA Research 2005 12(5):365-372; doi:10.1093/dnares/dsi017
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© The Author 2006. Kazusa DNA Research Institute
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

MATN and LAPTM Are Parts of Larger Transcription Units Produced by Intergenic Splicing: Intergenic Splicing May Be a Common Phenomenon

Koichi Maeda, Taizo Horikoshi, Eiji Nakashima, Yoshinari Miyamoto, Akihiko Mabuchi and Shiro Ikegawa*

Laboratory for Bone and Joint Diseases, SNP Research Center, The Institute of Physical and Chemical Research (RIKEN) 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

Intergenic splicing, the joining of exons from separate genes, has been observed only rarely in mammals. While the matrilin (MATN) and lysosomal-associated protein transmembrane (LAPTM) genes comprise distinct gene families, we have demonstrated intergenic splicing between two sets of family genes, the matrilin-3 (MATN3) and lysosomal-associated protein transmembrane 4{alpha} (LAPTM4A), and the matrilin-2 (MATN2) and lysosomal-associated protein transmembrane 4ß (LAPTM4B). The expression pattern and sub-cellular localization of the MATN–LAPTM hybrid transcripts differ from those of the original genes, suggesting unique functions for the products. Our observations indicate that intergenic splicing is a common and well-regulated phenomenon and underscore the fundamental challenges in defining the gene (transcriptional unit). Given these findings, the number of gene in the human genome may be smaller than present estimates suggest.

Key words: MATN3; LAPTM4A; intergenic splicing; hybrid mRNA; fusion protein

*To whom correspondence should be addressed. Tel./Fax. +81-3-5449-5393; E-mail: sikegawa{at}ims.u-tokyo.ac.jp

Communicated by Michio Oishi


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